Within the LEARN study we have developed a health-economic simulation model to reflect the potential of advanced diagnostic tests in relation to future disease-modifying treatments. A simplistic version of the model is made available. You can download the model by filling out the form below.
Publication of the model
- Handels RL, Joore MA, Tran-Duy A, Wimo A, Wolfs CA, Verhey FR, Severens JL. Early cost-utility analysis of general and cerebrospinal fluid-specific Alzheimer’s disease biomarkers for hypothetical disease-modifying treatment decision in mild cognitive impairment. Alzheimers Dement. 2015 Aug;11(8):896-905. doi: 10.1016/j.jalz.2015.02.009.
- Handels RL, Xu W, Rizzuto D, Caracciolo B, Wang R, Winblad B, Verhey FR, Severens JL, Fratiglioni L, Joore MA, Wimo A. Natural progression model of cognition and physical functioning among people with mild cognitive impairment and alzheimer’s disease. J Alzheimers Dis. 2013;37(2):357-65. doi: 10.3233/JAD-130296.
- Handels RL, Aalten P, Wolfs CA, OldeRikkert M, Scheltens P, Visser PJ, Joore MA, Severens JL, Verhey FR. Diagnostic and economic evaluation of new biomarkers for Alzheimer’s disease: the research protocol of a prospective cohort study. BMC Neurol. 2012 Aug 10;12:72.
21-01-2016: This is an adapted form of the model published in Alzheimer’s & Dementia: The Journal of the Alzheimer’s association.
Request a download URL